Proteomic analysis to display the effect of low doses of erythropoietin on rat liver regeneration

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10105393" target="_blank" >RIV/00216208:11150/11:10105393 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0024320511003997" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0024320511003997</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.lfs.2011.08.002" target="_blank" >10.1016/j.lfs.2011.08.002</a>

Result language
angličtina
Original language name
Proteomic analysis to display the effect of low doses of erythropoietin on rat liver regeneration
Original language description
The aim of the study was to investigate whether low doses of erythropoietin (EPO) can stimulate liver regeneration after partial hepatectomy. Parameters of liver regeneration were assessed 3 days after 70% hepatectomy by means of immunochemistry and proteomics. EPO was given twice in low dosages (200 and 600 IU/kg BW). We showed that EPO facilitated hepatic regeneration in rats. Enhanced hepatocyte proliferation (Ki67, BrdU-positive cells) was observed in all EPO-treated groups. By performing differential proteomic analysis, we identified two proteins which resulted sensitive to EPO treatment after hepatectomy: Peroxiredoxin-1 and glutathione S-transferase Mu 1.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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