Both Water Intoxication and Osmotic BBB Disruption Increase Brain Water Content in Rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189591" target="_blank" >RIV/00216208:11110/13:10189591 - isvavai.cz</a>

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/62%20Suppl%201/62_S75.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/62%20Suppl%201/62_S75.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Both Water Intoxication and Osmotic BBB Disruption Increase Brain Water Content in Rats

Original language description

Our previous experiments revealed that water intoxication and osmotic BBB disruption in the rat allow penetration of high-molecular substances into the brain and that resulting changes in the internal environment of the CNS lead to pathological development, such as the loss of integrity of myelin. The aim of the present study was to determine whether the previously described phenomena are associated with increased water content in the brain. To answer the question following methods were used: a) water intoxication: intraperitoneal administration of distilled water, b) osmotic BBB disruption: application of mannitol (20 %) selectively into the internal carotid artery, c) brain wet weight was measured after decapitation, and subsequently (after six daysin thermostat set at 86 degrees C) the dry weight were estimated d) in animals with 20 % and 30 % hyperhydration the degree of myelin deterioration was estimated e) animal locomotor activity was tested by continuous behavior tracking and

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

Suppl. 1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

"S75"-"S80"

UT code for WoS article

000328901900008

EID of the result in the Scopus database

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