Biochemical manifestations of the nervous tissue degradation after the blood-brain barrier opening or water intoxication in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10334419" target="_blank" >RIV/00216208:11110/16:10334419 - isvavai.cz</a>

Result on the web

<a href="http://www.nel.edu/archive_issues/o/37_2/37_2_Kozler_114-120.pdf" target="_blank" >http://www.nel.edu/archive_issues/o/37_2/37_2_Kozler_114-120.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Biochemical manifestations of the nervous tissue degradation after the blood-brain barrier opening or water intoxication in rats

Original language description

OBJECTIVES: The aim of the study was to determine changes of biomarkers of nervous tissue degradation in experimental model of osmotic blood-brain barrier opening or water intoxication and to find whether they correspond to changes in well defined clinical entities. METHODS: In the cerebro-spinal fluid taken via the suboccipital puncture, myelin basic protein (MBP ng/ml), neuron-specific enolase (NSE ng/ml) and TAU-protein (Tau pg/ml) were determined by ELISA in 19 controls and 29 experimental rats several hours or one week after the experimental intervention. RESULTS: Significant difference between the control and experimental groups was revealed only for the concentration of myelin basic protein. After the BBB opening, its level dramatically increased within hours and dropped back to control values within one week. Water intoxication induced only dilutional hypoproteinorachia. No significant changes were found in NSE and levels of TAU-protein were not detectable. CONCLUSION: 1. Increased permeability of cytoplasmic membranes induced by water intoxication does not alter any of monitored CSF biomarkers. 2. Osmotic opening of the BBB in vivo experiment without the presence of other pathological conditions leads to a damage of myelin, without impairment of neurons or their axons.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

37

Issue of the periodical within the volume

2

Country of publishing house

SE - SWEDEN

Number of pages

7

Pages from-to

114-120

UT code for WoS article

000391807100005

EID of the result in the Scopus database

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