Immunomodulatory properties of subcellular fractions of a G+ bacterium, Bacillus firmus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189736" target="_blank" >RIV/00216208:11110/13:10189736 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/13:00399949

Result on the web

<a href="http://dx.doi.org/10.1007/s12223-012-0181-y" target="_blank" >http://dx.doi.org/10.1007/s12223-012-0181-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12223-012-0181-y" target="_blank" >10.1007/s12223-012-0181-y</a>

Result language

angličtina

Original language name

Immunomodulatory properties of subcellular fractions of a G+ bacterium, Bacillus firmus

Original language description

Mucosal immunization with non-living antigens usually requires the use of an adjuvant. The adjuvant activity of Bacillus firmus in the mucosal immunization of mice was described by our laboratory previously. In the present study, subcellular localizationof B. firmus activities was followed. After mechanical disintegration, subcellular components of bacterium were fractionated by differential centrifugation and salting out. Bacterial cell walls, cytoplasmic membrane fraction, soluble cytoplasmic proteins, and ribosomal fractions were isolated. Their effect on the mouse immune system was studied. Lymphocyte proliferation and immunoglobulin formation in vitro were stimulated by bacterial cell wall (BCW), cytoplasmic membrane (CMF), and ribosomal fractions. BCW and CMF increased antibody formation after intratracheal immunization of mice with influenza A and B viruses, and increased protection against subsequent infection with influenza virus. The BCW fraction even induced intersubtypic c

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

<a href="/en/project/GA310%2F07%2F0675" target="_blank" >GA310/07/0675: Mucosal immunization by influenza virus type A</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Microbiologica

ISSN

0015-5632

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

11

Pages from-to

111-121

UT code for WoS article

000314409400003

EID of the result in the Scopus database

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