The restructuring of muscarinic receptor subtype gene transcripts in c-fos knock-out mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189773" target="_blank" >RIV/00216208:11110/13:10189773 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.brainresbull.2013.01.010" target="_blank" >http://dx.doi.org/10.1016/j.brainresbull.2013.01.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.brainresbull.2013.01.010" target="_blank" >10.1016/j.brainresbull.2013.01.010</a>

Result language
angličtina
Original language name
The restructuring of muscarinic receptor subtype gene transcripts in c-fos knock-out mice
Original language description
Although c-Fos plays a key role in intracellular signalling, the disruption of the c-fos gene has only minor consequences on the central nervous system (CNS) function. As muscarinic receptors (MR) play important roles in many CNS functions (attention, arousal, and cognition), the c-fos knock-out might be compensated through MR changes. The aim of this study was to evaluate changes in the M-1-M-5 MR mRNA in selected CNS areas: frontal, parietal, temporal and occipital cortex, striatum, hippocampus, hypothalamus and cerebellum (FC, PC, TC, OC, stria, hip, hypo, and crbl, respectively). Knocking out the c-fos gene changed the expression of MR in FC (reduced M1R, M4R and M5R expression), TC (increased M4R expression), OC (decreased M2R and M3R expression)and hippocampus (reduced M3R expression). Moreover, gender differences were observed in WT mice: increased expression of all M-1-M5R in the FC in males and M-1-M4R in the striatum in females. A detailed analysis of MR transcripts showed p
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—

Project
<a href="/en/project/GA309%2F09%2F0406" target="_blank" >GA309/09/0406: Muscarinic receptor regulation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)