Distinct Roles of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factors in Inflammatory Response and Cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190094" target="_blank" >RIV/00216208:11110/13:10190094 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1128/JVI.03315-12" target="_blank" >http://dx.doi.org/10.1128/JVI.03315-12</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/JVI.03315-12" target="_blank" >10.1128/JVI.03315-12</a>
Alternative languages
Result language
angličtina
Original language name
Distinct Roles of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factors in Inflammatory Response and Cancer
Original language description
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). Similar to other herpesviruses, KSHV has two life cycles, latency andlytic replication. In latency, the KSHV genome persists as a circular episome in the nucleus of the host cell and only a few viral genes are expressed. In this review, we focus on oncogenic, antiapoptotic, and immunomodulating properties of KSHV-encodedhomologues of cellular interferon regulatory factors (IRFs)-viral IRF1 (vIRF1) to vIRF4-and their possible role in the KSHV-mediated antiviral response, apoptosis, and oncogenicity.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA204%2F09%2F0773" target="_blank" >GA204/09/0773: Study of the oncogenic properties of the Kaposi's sarcoma-associated herpesvirus-encoded vIRF-3 using the method of RNA interference (RNAi)</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Virology
ISSN
0022-538X
e-ISSN
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Volume of the periodical
87
Issue of the periodical within the volume
17
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
9398-9410
UT code for WoS article
000323148500001
EID of the result in the Scopus database
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