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Distinct Roles of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factors in Inflammatory Response and Cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190094" target="_blank" >RIV/00216208:11110/13:10190094 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1128/JVI.03315-12" target="_blank" >http://dx.doi.org/10.1128/JVI.03315-12</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1128/JVI.03315-12" target="_blank" >10.1128/JVI.03315-12</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Distinct Roles of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factors in Inflammatory Response and Cancer

  • Original language description

    Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). Similar to other herpesviruses, KSHV has two life cycles, latency andlytic replication. In latency, the KSHV genome persists as a circular episome in the nucleus of the host cell and only a few viral genes are expressed. In this review, we focus on oncogenic, antiapoptotic, and immunomodulating properties of KSHV-encodedhomologues of cellular interferon regulatory factors (IRFs)-viral IRF1 (vIRF1) to vIRF4-and their possible role in the KSHV-mediated antiviral response, apoptosis, and oncogenicity.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA204%2F09%2F0773" target="_blank" >GA204/09/0773: Study of the oncogenic properties of the Kaposi's sarcoma-associated herpesvirus-encoded vIRF-3 using the method of RNA interference (RNAi)</a><br>

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Virology

  • ISSN

    0022-538X

  • e-ISSN

  • Volume of the periodical

    87

  • Issue of the periodical within the volume

    17

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    13

  • Pages from-to

    9398-9410

  • UT code for WoS article

    000323148500001

  • EID of the result in the Scopus database