Bone status in adults with early-onset juvenile idiopathic arthritis following 1-year anti-TNF alpha therapy and discontinuation of glucocorticoids

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190172" target="_blank" >RIV/00216208:11110/13:10190172 - isvavai.cz</a>

Alternative codes found

RIV/00023728:_____/13:#0004097

Result on the web

<a href="http://dx.doi.org/10.1007/s00296-013-2678-3" target="_blank" >http://dx.doi.org/10.1007/s00296-013-2678-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00296-013-2678-3" target="_blank" >10.1007/s00296-013-2678-3</a>

Result language

angličtina

Original language name

Bone status in adults with early-onset juvenile idiopathic arthritis following 1-year anti-TNF alpha therapy and discontinuation of glucocorticoids

Original language description

Juvenile idiopathic arthritis (JIA) is an inflammatory disease associated with bone loss and low bone mineral density (BMD). The treatment involves disease-modifying antirheumatic drugs, glucocorticoids (GCs) and biological agents. The aim of this studywas to evaluate effects of 12-month therapy with the anti-tumor necrosis factor alpha (anti-TNF alpha) preparations on bone mineral density (BMD) and biochemical turnover markers (BTM) in adult patients with JIA who were previously either treated or nottreated with glucocorticoids (GC) and to assess effects of the discontinuation of GCs on their bone status. Nineteen adult patients (12 women, 7 men) aged 18-33 years with active JIA were prospectively enrolled to receive the anti-TNF alpha therapy (infliximab, etanercept or adalimumab). BMD and BTMs were determined at baseline and 1-year follow-up. The anti-TNF alpha therapy resulted in a significant reduction in disease activity score 28 (DAS28) and C-reactive protein (CRP) and a signi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Rheumatology International

ISSN

0172-8172

e-ISSN

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Volume of the periodical

33

Issue of the periodical within the volume

8

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

2001-2007

UT code for WoS article

000322120400012

EID of the result in the Scopus database

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