Brain dynamic neurochemical changes in dystonic patients: A magnetic resonance spectroscopy study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190733" target="_blank" >RIV/00216208:11110/13:10190733 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/mds.25279" target="_blank" >http://dx.doi.org/10.1002/mds.25279</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mds.25279" target="_blank" >10.1002/mds.25279</a>
Alternative languages
Result language
angličtina
Original language name
Brain dynamic neurochemical changes in dystonic patients: A magnetic resonance spectroscopy study
Original language description
Measurements of the concentrations of -aminobutyric acid (GABA) and glutamate in the motor cortices and lentiform nuclei of dystonic patients using single-voxel 1H magnetic resonance spectroscopy (MRS) have yielded conflicting results so far. This studyaimed to investigate dynamic changes in metabolite concentrations after stimulation of the motor cortices in patients with upper limb dystonia. Using single-voxel MRS at 3 T, the concentrations of GABA, glutamate plus glutamine, and N-acetylaspartate were measured bilaterally in the primary sensorimotor cortex, lentiform nucleus, and occipital region before and after 5-Hz transcranial magnetic stimulation (TMS) over the dominant motor cortex. Data obtained from 15 patients with upper limb primary dystonia were compared with data obtained from 14 healthy volunteers. At baseline, there was no group difference in concentration of metabolites in any region. rTMS induced a local (in the stimulated motor cortex) decrease of N-acetylaspartate
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Movement Disorders
ISSN
0885-3185
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
201-209
UT code for WoS article
000315399300015
EID of the result in the Scopus database
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