Objective Acoustic Quantification of Phonatory Dysfunction in Huntington's Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10191005" target="_blank" >RIV/00216208:11110/13:10191005 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/13:00206221 RIV/00064165:_____/13:10191005
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0065881" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0065881</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0065881" target="_blank" >10.1371/journal.pone.0065881</a>
Alternative languages
Result language
angličtina
Original language name
Objective Acoustic Quantification of Phonatory Dysfunction in Huntington's Disease
Original language description
Purpose: Although speech motor changes are reported as a common sign of Huntington's disease (HD), the most prominent signs of voice dysfunction remain unknown. The aim of the current study was to explore specific changes in phonatory function in subjects with HD. Method: 34 subjects with HD and 34 age- and sex-matched healthy controls were examined. Participants performed sustained vowel phonation for subsequent analyses of airflow insufficiency, aperiodicity, irregular vibrations of vocal folds, signal perturbations, increased noise, and articulation deficiency. In total, 272 phonations were collected and 12 voice parameters were extracted. Subsequently, a predictive model was built to find the most salient patterns of voice disorders in HD. The results were also correlated with disease severity according to the Unified HD Rating Scale (UHDRS) motor score. Results: Subjects with HD showed deterioration in all investigated phonatory functions. Irregular pitch fluctuations, sudden phon
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
—
Volume of the periodical
8
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
—
UT code for WoS article
000320440500056
EID of the result in the Scopus database
—