Phonatory Dysfunction as a Preclinical Symptom of Huntington Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10285022" target="_blank" >RIV/00216208:11110/14:10285022 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21230/14:00221825

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pone.0113412" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0113412</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0113412" target="_blank" >10.1371/journal.pone.0113412</a>

Result language

angličtina

Original language name

Phonatory Dysfunction as a Preclinical Symptom of Huntington Disease

Original language description

Purpose: Although dysphonia has been shown to be a common sign of Huntington disease (HD), the extent of phonatory dysfunction in gene positive premanifest HD individuals remains unknown. The aim of the current study was to explore the possible occurrence of phonatory abnormalities in prodromal HD. Method: Sustained vowel phonations were acquired from 28 premanifest HD individuals and 28 healthy controls of comparable age. Data were analysed acoustically for measures of several phonatory dimensions including airflow insufficiency, aperiodicity, irregular vibration of vocal folds, signal perturbations, increased noise, vocal tremor and articulation deficiency. A predictive model was built to find the best combination of acoustic features and estimate sensitivity/specificity for differentiation between premanifest HD subjects and controls. The extent of voice deficits according to a specific phonatory dimension was determined using statistical decision making theory. The results were cor

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/GAP102%2F12%2F2230" target="_blank" >GAP102/12/2230: Acoustic voice and speech analysis in patients with central nervous system disorders</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS ONE

ISSN

1932-6203

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

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UT code for WoS article

000345533200115

EID of the result in the Scopus database

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