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Strontium ranelate: in search for the mechanism of action

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10191386" target="_blank" >RIV/00216208:11110/13:10191386 - isvavai.cz</a>

  • Alternative codes found

    RIV/00023728:_____/13:#0004113

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s00774-013-0494-1" target="_blank" >http://dx.doi.org/10.1007/s00774-013-0494-1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00774-013-0494-1" target="_blank" >10.1007/s00774-013-0494-1</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Strontium ranelate: in search for the mechanism of action

  • Original language description

    Strontium ranelate is a medicine with evidenced effects on the risk of fractures. The heterogeneity of strontium distribution in bone, quality of bone mineral crystals in young bone packets on bone surfaces formed during strontium ranelate administration, and activation of the calcium sensing receptor may, at least partially, explain the beneficial effects of SrR on reducing the risk of fractures. In this review, the concept of the dual action of strontium ranelate is also discussed. However, sufficientevidence for the bone anabolic effect of SrR does not exist in humans. The knowledge of the mechanism of action of SrR is important not only for the explanation of the effects of SrR upon the skeleton, but also for the safety of treatment for other tissues.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FE - Other fields of internal medicine

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Bone and Mineral Metabolism

  • ISSN

    0914-8779

  • e-ISSN

  • Volume of the periodical

    31

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    JP - JAPAN

  • Number of pages

    7

  • Pages from-to

    606-612

  • UT code for WoS article

    000326924400001

  • EID of the result in the Scopus database