Strontium ranelate: in search for the mechanism of action
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10191386" target="_blank" >RIV/00216208:11110/13:10191386 - isvavai.cz</a>
Alternative codes found
RIV/00023728:_____/13:#0004113
Result on the web
<a href="http://dx.doi.org/10.1007/s00774-013-0494-1" target="_blank" >http://dx.doi.org/10.1007/s00774-013-0494-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00774-013-0494-1" target="_blank" >10.1007/s00774-013-0494-1</a>
Alternative languages
Result language
angličtina
Original language name
Strontium ranelate: in search for the mechanism of action
Original language description
Strontium ranelate is a medicine with evidenced effects on the risk of fractures. The heterogeneity of strontium distribution in bone, quality of bone mineral crystals in young bone packets on bone surfaces formed during strontium ranelate administration, and activation of the calcium sensing receptor may, at least partially, explain the beneficial effects of SrR on reducing the risk of fractures. In this review, the concept of the dual action of strontium ranelate is also discussed. However, sufficientevidence for the bone anabolic effect of SrR does not exist in humans. The knowledge of the mechanism of action of SrR is important not only for the explanation of the effects of SrR upon the skeleton, but also for the safety of treatment for other tissues.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Bone and Mineral Metabolism
ISSN
0914-8779
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
6
Country of publishing house
JP - JAPAN
Number of pages
7
Pages from-to
606-612
UT code for WoS article
000326924400001
EID of the result in the Scopus database
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