The combination of mesenchymal stem cells and a bone scaffold in the treatment of vertebral body defects

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10191611" target="_blank" >RIV/00216208:11110/13:10191611 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/13:00397075 RIV/68378041:_____/13:00397075 RIV/68378297:_____/13:00397075 RIV/00216208:11130/13:10191611 and 4 more
Result on the web
<a href="http://dx.doi.org/10.1007/s00586-013-2991-2" target="_blank" >http://dx.doi.org/10.1007/s00586-013-2991-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00586-013-2991-2" target="_blank" >10.1007/s00586-013-2991-2</a>

Result language
angličtina
Original language name
The combination of mesenchymal stem cells and a bone scaffold in the treatment of vertebral body defects
Original language description
Vertebral body defects represent one of the most common orthopedic challenges. In order to advance the transfer of stem cell therapies into orthopedic clinical practice, we performed this study to evaluate the safety and efficacy of a composite bioartificial graft based on a hydroxyapatite bone scaffold (CEM-OSTETICA (R)) combined with human mesenchymal stem cells (MSCs) in a rat model of vertebral body defects. Under general isoflurane anesthesia, a defect in the body of the L-2 vertebra was prepared and left to heal spontaneously (group 1), implanted with scaffold material alone (group 2), or implanted with a scaffold together with 0.5 million MSCs (group 3) or 5 million MSCs (group 4). The rats were killed 8 weeks after surgery. Histological and histomorphometrical evaluation of the implant as well as micro-CT imaging of the vertebrae were performed. We observed a significant effect on the formation of new bone tissue in the defect in group 4 when compared to the other groups and a
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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