Evolution of cortical and thalamus atrophy and disability progression in early relapsing-remitting MS during 5 years

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193029" target="_blank" >RIV/00216208:11110/13:10193029 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/13:10193029
Result on the web
<a href="http://dx.doi.org/10.3174/ajnr.A3503" target="_blank" >http://dx.doi.org/10.3174/ajnr.A3503</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3174/ajnr.A3503" target="_blank" >10.3174/ajnr.A3503</a>

Result language
angličtina
Original language name
Evolution of cortical and thalamus atrophy and disability progression in early relapsing-remitting MS during 5 years
Original language description
BACKGROUND AND PURPOSE: Pathologic changes inGMhave an important role in MS.Weinvestigated the association between SDGM and cortical volume changes and disability progression in early RRMS. MATERIALS AND METHODS: One hundred eighty patients with RRMS hadclinical assessment during 5 years and were divided into those with or without SDP at 5 years by the usual definition in treatment trials. The number of available MR imaging scans at various time points was the following: at baseline, 178; and at 6 months, 172; at 12 months, 175; at 24 months, 155; at 36 months, 160; at 48 months, 158; and at 60 months, 162, respectively. Longitudinal changes in cortical, GM, and WM volume were calculated by using the direct method. RESULTS: At 5 years, 90 patients with RRMS experienced SDP and 90 had stable disease. At baseline, patients with SDP had longer disease duration, greater T2-lesion volume, and smaller whole-brain, WM, cortical, and SDGM volume (P < .01). At 5 years, patients with SDP had si
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/NT13237" target="_blank" >NT13237: Clinical and paraclinical markers of multiple sclerosis – description and prediction of disease activity</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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