MRI correlates of disability progression in patients with CIS over 48 months

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10285638" target="_blank" >RIV/00216208:11110/14:10285638 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/14:10285638
Result on the web
<a href="http://dx.doi.org/10.1016/j.nicl.2014.09.015" target="_blank" >http://dx.doi.org/10.1016/j.nicl.2014.09.015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.nicl.2014.09.015" target="_blank" >10.1016/j.nicl.2014.09.015</a>

Result language
angličtina
Original language name
MRI correlates of disability progression in patients with CIS over 48 months
Original language description
Background Gray matter (GM) and white matter (WM) pathology has an important role in disease progression of multiple sclerosis (MS). Objectives To investigate the association between the development of GM and WM pathology and clinical disease progressionin patients with clinically isolated syndrome (CIS). Methods This prospective, observational, 48-month follow-up study examined 210 CIS patients treated with 30 ?g of intramuscular interferon beta-1a once a week. MRI and clinical assessments were performed at baseline, 6, 12, 24, 36 and 48 months. Associations between clinical worsening [24-weeks sustained disability progression (SDP) and occurrence of a second clinical attack] and longitudinal changes in lesion accumulation and brain atrophy progression were investigated by a mixed-effect model analysis after correction for multiple comparisons. Results SDP was observed in 32 (15.2%) CIS patients, while 146 (69.5%) were stable and 32 (15.2%) showed sustained disability improvement. 11
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/NT13237" target="_blank" >NT13237: Clinical and paraclinical markers of multiple sclerosis – description and prediction of disease activity</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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