Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193357" target="_blank" >RIV/00216208:11110/13:10193357 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/13:10193357

Result on the web

<a href="http://dx.doi.org/10.1186/ar4311" target="_blank" >http://dx.doi.org/10.1186/ar4311</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/ar4311" target="_blank" >10.1186/ar4311</a>

Result language

angličtina

Original language name

Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis

Original language description

Introduction: The aetiopathogenesis of juvenile dermatomyositis (JDM) remains poorly understood. In particular the contribution of monocytes or macrophages, which are frequently observed to be an infiltrate within muscle tissue very early in the diseaseprocess, is unknown. We hypothesised that these cells secrete the pro-inflammatory myeloid related protein (MRP) 8/14 which may then contribute to muscle pathology in JDM. Methods: In this study of 56 JDM patients, serum MRP8/14 levels were compared withclinical measures of disease activity. Muscle biopsies taken early in disease were assessed by immunohistochemistry to determine the frequency and identity of MRP-expressing cells. The effects of MRP stimulation and endoplasmic reticulum (ER) stress onmuscle were tested in vitro. Serum or supernatant levels of cytokines were analyzed by multiplex immunoassay. Results: Serum MRP8/14 correlated with physician's global assessment of disease activity in JDM (R = 0.65, p = 0.0003) and muscl

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FG - Paediatrics

OECD FORD branch

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Project

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Continuities

R - Projekt Ramcoveho programu EK

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Arthritis Research & Therapy

ISSN

1478-6362

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

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UT code for WoS article

000329737400031

EID of the result in the Scopus database

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