Markers of HPV infection and survival in patients with head and neck tumors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10194021" target="_blank" >RIV/00216208:11110/13:10194021 - isvavai.cz</a>
Alternative codes found
RIV/00023736:_____/13:00010734 RIV/00216208:11130/13:10194021 RIV/00064203:_____/13:10194021
Result on the web
<a href="http://dx.doi.org/10.1002/ijc.28194" target="_blank" >http://dx.doi.org/10.1002/ijc.28194</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ijc.28194" target="_blank" >10.1002/ijc.28194</a>

Result language
angličtina
Original language name
Markers of HPV infection and survival in patients with head and neck tumors
Original language description
The purpose of this study was to determine whether changes in human papillomavirus (HPV) DNA prevalence in oral rinses and/or HPV-specific antibody levels in the sera of patients with oral/oropharyngeal cancer have prognostic significance. We enrolled 142 patients with oral/oropharyngeal tumors. The presence of HPV DNA was assayed in tumor tissue and oral rinses and HPV-specific antibodies were assessed in the sera. Oral rinses and sera were collected before and after the treatment. Altogether, 59.2% oftumors were HPV positive. The presence of HPV DNA in the tumors correlated with HPV DNA positivity in oral rinses and with HPV-specific antibodies in the sera. Out of 66 patients with HPV-positive oral rinses at enrolment, 84.8% became negative after the therapy, while most patients remained seropositive for HPV-specific antigens. However, the mean titers of HPV16 E6 and/or E7 antibodies at follow-up were significantly lower. Of 16 patients with recurrences at follow-up, six were positi
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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