A transgenic minipig model of huntington's disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10194896" target="_blank" >RIV/00216208:11110/13:10194896 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/13:10194896 RIV/00064165:_____/13:10194896 RIV/00027162:_____/13:#0001011
Result on the web
<a href="http://www.iapg.cas.cz/uzfg/files/files/A_transgenic_Minipig_Model_of_Huntingtons_Disease.pdf" target="_blank" >http://www.iapg.cas.cz/uzfg/files/files/A_transgenic_Minipig_Model_of_Huntingtons_Disease.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/JHD-130001" target="_blank" >10.3233/JHD-130001</a>
Alternative languages
Result language
angličtina
Original language name
A transgenic minipig model of huntington's disease
Original language description
One copy of the human HTT transgene encoding 124 glutamines integrated into chromosome 1 q24-q25 and successful germ line transmission occurred through successive generations (F0, F1, F2 and F3 generations). No developmental or gross motor deficits werenoted up to 40 months of age. Mutant HTTmRNAand protein fragment were detected in brain and peripheral tissues. No aggregate formation in brain up to 16 months was seen by AGERA and filter retardation or by immunostaining. DARPP32 labeling in WT and TgHDminipig neostriatum was patchy. Analysis of 16 month old siblings showed reduced intensity of DARPP32 immunoreactivity in neostriatal TgHD neurons compared to those of WT. Compared to WT, TgHD boars by one year had reduced fertility and fewer spermatozoa per ejaculate. In vitro analysis revealed a significant decline in the number of WT minipig oocytes penetrated by TgHD spermatozoa.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Huntington's disease
ISSN
1879-6397
e-ISSN
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Volume of the periodical
2
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
22
Pages from-to
47-68
UT code for WoS article
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EID of the result in the Scopus database
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