MDR1 in Paroxetine-Induced Sexual Dysfunction

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10195511" target="_blank" >RIV/00216208:11110/13:10195511 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/13:00067710
Result on the web
<a href="http://dx.doi.org/10.1080/0092623X.2012.668514" target="_blank" >http://dx.doi.org/10.1080/0092623X.2012.668514</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/0092623X.2012.668514" target="_blank" >10.1080/0092623X.2012.668514</a>

Result language
angličtina
Original language name
MDR1 in Paroxetine-Induced Sexual Dysfunction
Original language description
Paroxetine-induced sexual dysfunction represents a frequent treatment complication of otherwise efficient antidepressants. The genetic polymorphism of pharmacokinetic genes may contribute to the occurrence of such dysfunctions. This study presents the effect of MDR1 gene polymorphisms on sexual function in 18 women with bulimia nervosa, 18 women with anxiety disorders, and 19 healthy control subjects. It also deals with the relation between MDR1 gene polymorphisms and paroxetine-induced sexual dysfunction. The results demonstrated that MDR1 G2677T/A gene polymorphism allele carriers treated with paroxetine presented with difficulties with orgasm (p=.008) and lubrication (p<.001).
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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