Both autologous bone marrow mononuclear cell and peripheral blood progenitor cell therapies similarly improve ischaemia in patients with diabetic foot in comparison with control treatment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10209732" target="_blank" >RIV/00216208:11110/13:10209732 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/13:00396598 RIV/00216208:11130/13:10209732 RIV/00023001:_____/13:00058648
Result on the web
<a href="http://dx.doi.org/10.1002/dmrr.2399" target="_blank" >http://dx.doi.org/10.1002/dmrr.2399</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/dmrr.2399" target="_blank" >10.1002/dmrr.2399</a>

Result language
angličtina
Original language name
Both autologous bone marrow mononuclear cell and peripheral blood progenitor cell therapies similarly improve ischaemia in patients with diabetic foot in comparison with control treatment
Original language description
Background The aim of our study was to compare the effect of bone marrow mononuclear cell and peripheral blood progenitor cell therapies in patients with diabetic foot disease and critical limb ischaemia unresponsive to revascularization with conservative therapy. Methods Twenty-eight patients with diabetic foot disease (17 treated by bone marrow cells and 11 by peripheral blood cell) were included into an active group and 22 patients into a control group without cell treatment. Transcutaneous oxygen pressure and rate of major amputation, as the main outcome measures, were compared between bone marrow cells, peripheral blood cell and control groups over 6months; both cell therapy methods were also compared by the characteristics of cell suspensions. Possible adverse events were evaluated by changes of serum levels of angiogenic cytokines and retinal fundoscopic examination. Results The transcutaneous oxygen pressure increased significantly (p<0.05) compared with baseline in both active
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
<a href="/en/project/GAP304%2F11%2F0653" target="_blank" >GAP304/11/0653: Targeted differentiation and transdifferentiation of limbal and mesenchymal stem cells and their therapeutic applications in preclinical models</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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