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Elastic three-dimensional poly (epsilon-caprolactone) nanofibre scaffold enhances migration, proliferation and osteogenic differentiation of mesenchymal stem cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10209796" target="_blank" >RIV/00216208:11110/13:10209796 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378041:_____/13:00397649 RIV/00216208:11130/13:10209796 RIV/49777513:23520/13:43918199 RIV/49777513:23640/13:43918199 RIV/00064165:_____/13:10209796

  • Result on the web

    <a href="http://dx.doi.org/10.1111/cpr.12001" target="_blank" >http://dx.doi.org/10.1111/cpr.12001</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/cpr.12001" target="_blank" >10.1111/cpr.12001</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Elastic three-dimensional poly (epsilon-caprolactone) nanofibre scaffold enhances migration, proliferation and osteogenic differentiation of mesenchymal stem cells

  • Original language description

    Objectives We prepared 3D poly (e-caprolactone) (PCL) nanofibre scaffolds and tested their use for seeding, proliferation, differentiation and migration of mesenchymal stem cell (MSCs). Materials and methods 3D nanofibres were prepared using a special collector for common electrospinning; simultaneously, a 2D PCL nanofibre layer was prepared using a classic plain collector. Both scaffolds were seeded with MSCs and biologically tested. MSC adhesion, migration, proliferation and osteogenic differentiationwere investigated. Results The 3D PCL scaffold was characterized by having better biomechanical properties, namely greater elasticity and resistance against stress and strain, thus this scaffold will be able to find broad applications in tissue engineering. Clearly, while nanofibre layers of the 2D scaffold prevented MSCs from migrating through the conformation, cells infiltrated freely through the 3D scaffold. MSC adhesion to the 3D nanofibre PCL layer was also statistically more commo

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cell Proliferation

  • ISSN

    0960-7722

  • e-ISSN

  • Volume of the periodical

    46

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    15

  • Pages from-to

    23-37

  • UT code for WoS article

    000313245200003

  • EID of the result in the Scopus database