Elastic three-dimensional poly (epsilon-caprolactone) nanofibre scaffold enhances migration, proliferation and osteogenic differentiation of mesenchymal stem cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10209796" target="_blank" >RIV/00216208:11110/13:10209796 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/13:00397649 RIV/00216208:11130/13:10209796 RIV/49777513:23520/13:43918199 RIV/49777513:23640/13:43918199 RIV/00064165:_____/13:10209796
Result on the web
<a href="http://dx.doi.org/10.1111/cpr.12001" target="_blank" >http://dx.doi.org/10.1111/cpr.12001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/cpr.12001" target="_blank" >10.1111/cpr.12001</a>
Alternative languages
Result language
angličtina
Original language name
Elastic three-dimensional poly (epsilon-caprolactone) nanofibre scaffold enhances migration, proliferation and osteogenic differentiation of mesenchymal stem cells
Original language description
Objectives We prepared 3D poly (e-caprolactone) (PCL) nanofibre scaffolds and tested their use for seeding, proliferation, differentiation and migration of mesenchymal stem cell (MSCs). Materials and methods 3D nanofibres were prepared using a special collector for common electrospinning; simultaneously, a 2D PCL nanofibre layer was prepared using a classic plain collector. Both scaffolds were seeded with MSCs and biologically tested. MSC adhesion, migration, proliferation and osteogenic differentiationwere investigated. Results The 3D PCL scaffold was characterized by having better biomechanical properties, namely greater elasticity and resistance against stress and strain, thus this scaffold will be able to find broad applications in tissue engineering. Clearly, while nanofibre layers of the 2D scaffold prevented MSCs from migrating through the conformation, cells infiltrated freely through the 3D scaffold. MSC adhesion to the 3D nanofibre PCL layer was also statistically more commo
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Proliferation
ISSN
0960-7722
e-ISSN
—
Volume of the periodical
46
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
23-37
UT code for WoS article
000313245200003
EID of the result in the Scopus database
—