Polycaprolactone Nanofibrous Layer Functionalized by Thrombocyte Rich Solution

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F13%3A%230001756" target="_blank" >RIV/46747885:24410/13:#0001756 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Polycaprolactone Nanofibrous Layer Functionalized by Thrombocyte Rich Solution
Original language description
Tissue engineering applications widely use nanofibrous scaffolds due to their similarity to native extracellular matrix. Polycaprolactone (PCL) nanofibers have excellent properties for cell attachment. The platelet growth factors promote cell proliferation. Platelet rich plasma is clinically used in chronic wound treatment and in orthopedic applications (nonunionized fractures, total joint replacement). The aim of presented study is the development of nanofibrous layers functionalized by thrombocytes. The effect of platelet growth factors for fibroblast proliferation was tested. PCL nanofibers were immersed for 2 hours in thrombocyte rich solution (TRS) to enable thrombocyte adhesion. These scaffolds were thereafter seeded with fibroblasts. PCL nanofibrous layers without immobilized thrombocytes were used as a control. The presence of thrombocytes after 2 hour incubation was confirmed by scanning electrone microscopy (SEM). Proliferation of seeded fibroblasts on functionalized scaffold
Czech name
—
Czech description
—

Project
<a href="/en/project/GAP208%2F12%2F0105" target="_blank" >GAP208/12/0105: POLYMER SOLUTIONS IN AN EXTERNAL FIELD: MOLECULAR UNDERSTANDING OF ELECTROSPINNING</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)