Nanofibrous polycaprolactone scaffolds with adhered platelets stimulate proliferation of skin cells.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00469062" target="_blank" >RIV/68378041:_____/16:00469062 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/16:10327795
Result on the web
<a href="http://dx.doi.org/10.1111/cpr.12276" target="_blank" >http://dx.doi.org/10.1111/cpr.12276</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/cpr.12276" target="_blank" >10.1111/cpr.12276</a>

Result language
angličtina
Original language name
Nanofibrous polycaprolactone scaffolds with adhered platelets stimulate proliferation of skin cells.
Original language description
ObjectivesFaulty wound healing is a global healthcare problem. Chronic wounds are generally characterized by a reduction in availability of growth factors. New strategies are being developed to deliver growth factors more effectively. nnMethodsIn this study, we introduced electrospun scaffolds composed of polycaprolactone (PCL) nanofibers functionalized with adhered platelets, as a source of numerous growth factors. Three concentrations of platelets were immobilized to nanofibrous scaffolds by simple adhesion, and their influence on adhesion, proliferation and metabolic activity of seeded cells (murine fibroblasts, keratinocytes and melanocytes) was investigated. nnResultsThe data obtained indicated that presence of platelets significantly promoted cell spreading, proliferation and metabolic activity in all the skin-associated cell types. There were no significant differences among tested concentrations of platelets, thus even the lowest concentration sufficiently promoted proliferation of the seeded cells. nnConclusionsSuch complex stimulation is needed for improved healing of chronic wounds. However, the nanofibrous system can be used not only as a skin cover, but also in broader applications in regenerative medicine.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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