Nanofibrous Polycaprolactone Scaffold with Adhered Platelets Stimulates Proliferation of Skin Cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21720%2F16%3A00300671" target="_blank" >RIV/68407700:21720/16:00300671 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21460/16:00300671
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/cpr.12276/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/cpr.12276/epdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/cpr.12276" target="_blank" >10.1111/cpr.12276</a>

Result language
angličtina
Original language name
Nanofibrous Polycaprolactone Scaffold with Adhered Platelets Stimulates Proliferation of Skin Cells
Original language description
Faulty wound healing is a global healthcare problem. Chronic wounds are generally characterized by a decrease in the availability of growth factors. New strategies are being developed to deliver growth factors more effectively. In this study, we introduced electrospun scaffolds composed of polycaprolactone (PCL) nanofibers functionalized with adhered platelets as a source of numerous growth factors. Different concentrations of platelets were immobilized to nanofibrous scaffolds by simple adhesion and their influence on adhesion, proliferation and metabolic activity of the seeded cells (murine fibroblasts, keratinocytes and melanocytes) was investigated. The data showed the presence of platelets significantly promoted cell spreading, proliferation and metabolic activity in all the skin-associated cell types. There were no significant differences among the tested concentrations of platelets, thus even the lowest tested concentration sufficiently promoted proliferation of the seeded cells. Such complex stimulation is needed for improved healing of chronic wounds. However, the nanofibrous system can be used not only as a skin cover, but for broader applications in regenerative medicine as well.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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