Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10210039" target="_blank" >RIV/00216208:11110/13:10210039 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/13:00392100
Result on the web
<a href="http://dx.doi.org/10.1093/cvr/cvs329" target="_blank" >http://dx.doi.org/10.1093/cvr/cvs329</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/cvr/cvs329" target="_blank" >10.1093/cvr/cvs329</a>

Result language
angličtina
Original language name
Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans
Original language description
Human genome-wide association studies (GWAS) of hypertension identified only few susceptibility loci with large effect that were replicated across populations. The vast majority of genes detected by GWAS has small effect and the regulatory mechanisms through which these genetic variants cause disease remain mostly unclear. Here, we used comparative genomics between human and an established rat model of hypertension to explore the transcriptional mechanisms mediating the effect of genes identified in 15hypertension GWAS. Time series analysis of radiotelemetric blood pressure (BP) was performed to assess 11 parameters of BP variation in recombinant inbred strains derived from the spontaneously hypertensive rat. BP data were integrated with approximate to 27 000 expression quantative trait loci (eQTLs) mapped across seven tissues, detecting 8000 significant associations between eQTL genes and BP variation in the rat. We then compiled a large catalogue of human genes from GWAS of hyperten
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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