Hydrogen sulfide in cell signaling, signal transduction, cellular bioenergetics and physiology in C. elegans

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10210041" target="_blank" >RIV/00216208:11110/13:10210041 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.4149/gpb_2013001" target="_blank" >http://dx.doi.org/10.4149/gpb_2013001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/gpb_2013001" target="_blank" >10.4149/gpb_2013001</a>

Result language

angličtina

Original language name

Hydrogen sulfide in cell signaling, signal transduction, cellular bioenergetics and physiology in C. elegans

Original language description

Hydrogen sulfide (H2S), long viewed as a toxic gas and environmental hazard, is emerging as a biological mediator with remarkable physiological and pathophysiological relevance. H2S is now viewed as the third main gasotransmitter in the mammalian body. Its pharmacological characteristic possesses similarities to the other two gasotransmitters - nitric oxide (NO) and carbon monoxide (CO). Many of the biological effects of H2S follow a bell-shaped concentration-response; at low concentration or at lower release rates it has beneficial and cytoprotective effects, while at higher concentrations or fast release rates toxicity becomes apparent. Cellular bioenergetics is a prime example for this bell-shaped dose-response, where H2S, at lower concentrations/rates serves as an inorganic substrate and electron donor for mitochondrial ATP generation, while at high concentration it inhibits mitochondrial respiration by blocking the Complex IV in the mitochondrial electron transport chain. The curr

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

General Physiology and Biophysics

ISSN

0231-5882

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

22

Pages from-to

1-22

UT code for WoS article

000319533200001

EID of the result in the Scopus database

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