Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10196519" target="_blank" >RIV/00216208:11110/14:10196519 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/14:10196519
Result on the web
<a href="http://dx.doi.org/10.1038/onc.2013.414" target="_blank" >http://dx.doi.org/10.1038/onc.2013.414</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/onc.2013.414" target="_blank" >10.1038/onc.2013.414</a>

Result language
angličtina
Original language name
Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice
Original language description
PU.1 downregulation within hematopoietic stem and progenitor cells (HSPCs) is the primary mechanism for the development of acute myeloid leukemia (AML) in mice with homozygous deletion of the upstream regulatory element (URE) of PU.1 gene. p53 is a well-known tumor suppressor that is often mutated in human hematologic malignancies including AML and adds to their aggressiveness; however, its genetic deletion does not cause AML in mouse.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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