Quantification of circulating fetal DNA as a tool for potential monitoring of pregnant patients with antiphospholipid antibodies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10210919" target="_blank" >RIV/00216208:11110/14:10210919 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/14:10210919 RIV/00064165:_____/14:10210919

Result on the web

<a href="http://informahealthcare.com/doi/abs/10.3109/08916934.2014.917372" target="_blank" >http://informahealthcare.com/doi/abs/10.3109/08916934.2014.917372</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/08916934.2014.917372" target="_blank" >10.3109/08916934.2014.917372</a>

Result language

angličtina

Original language name

Quantification of circulating fetal DNA as a tool for potential monitoring of pregnant patients with antiphospholipid antibodies

Original language description

Abstract Apoptosis of tissues of fetal origin is thought to be one of the main sources of cell-free fetal DNA (cffDNA) in maternal circulation, impaired apoptosis is also involved in the mechanisms contributing to recurrent spontaneous miscarriages (RSM)associated with antiphospholipid syndrome (APS). The APS increases the risk for preeclampsia nine times. In preeclampsia, the elevated levels of cffDNA were described by different authors. To our knowledge, cffDNA in pregnant patients with APS was neverstudied. In our pilot study, we focused on the levels of cffDNA in four pregnant patients with treated primary APS and compared them with values obtained in twenty-one healthy subjects of comparable gestation age (the third trimester of pregnancy). We supposed that the increase of cffDNA concentration in our treated patients would signalize the elevated apoptosis of fetal tissues as in other pathological changes of placentation. The aim of our pilot study was to determine cffDNA concent

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Autoimmunity

ISSN

0891-6934

e-ISSN

—

Volume of the periodical

47

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

473-477

UT code for WoS article

000344331700008

EID of the result in the Scopus database

—