Deoxyribonuclease activity in plasma of pregnant women and experimental animals

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10369796" target="_blank" >RIV/00216208:11150/18:10369796 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/18:10369796
Result on the web
<a href="http://dx.doi.org/10.1080/14767058.2017.1326899" target="_blank" >http://dx.doi.org/10.1080/14767058.2017.1326899</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/14767058.2017.1326899" target="_blank" >10.1080/14767058.2017.1326899</a>

Result language
angličtina
Original language name
Deoxyribonuclease activity in plasma of pregnant women and experimental animals
Original language description
Clinical observations and animal experiments have shown that higher fetal DNA in maternal plasma could participate on the pathogenesis of preeclampsia. The understudied factor that could participate in interindividual variability in cell-free DNA is enzymatic activity of deoxyribonuclease (DNase). We have found that healthy pregnant animals have higher plasma DNase activity than healthy pregnant women. Injection of cell-free fetal DNA into pregnant animals had no effect on DNase activity. Interspecies differences in DNase activity should be considered in animal experiments focusing on the role of fetal DNA in preeclampsia and cell-free DNA in other disease models.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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