Humoral responses to herpesviruses are associated with neurodegeneration after a demyelinating event: Results from the Multi-Center SET study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10271650" target="_blank" >RIV/00216208:11110/14:10271650 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/14:10271650
Result on the web
<a href="http://dx.doi.org/10.1016/j.jneuroim.2014.04.012" target="_blank" >http://dx.doi.org/10.1016/j.jneuroim.2014.04.012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jneuroim.2014.04.012" target="_blank" >10.1016/j.jneuroim.2014.04.012</a>

Result language
angličtina
Original language name
Humoral responses to herpesviruses are associated with neurodegeneration after a demyelinating event: Results from the Multi-Center SET study
Original language description
Objectives: To investigate the associations between antibody responses to herpesviruses and the development of thalamic, total deep graymatter, cortical and central atrophy in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. Methods:We analyzed volumetric brain outcomes in 193 CIS patients enrolled in amulti-center study of high-risk CIS. All patients had 2 or more MRI brain lesions and two or more oligoclonal bands in cerebrospinal fluid. Serum samples obtained at thescreening visit prior to any treatment were analyzed for IgG antibodies against cytomegalovirus (anti-CMV) and Epstein-Barr virus (EBV) viral capsid antigen (VCA). All patients were treated with interferon-beta. Clinical and MRI assessments were obtainedat baseline, 6, 12, and 24 months. Results: Anti-EBV VCA highest quartile status was associatedwith regional atrophymeasures for percent decrease in thalamus. Anti-CMV positivity was associated with greater total deep gray matter atrophy
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/NT13237" target="_blank" >NT13237: Clinical and paraclinical markers of multiple sclerosis – description and prediction of disease activity</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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