Thalamic atrophy and cognitive impairment in clinically isolated syndrome and multiple sclerosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150096" target="_blank" >RIV/61989592:15110/14:33150096 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/14:#0000713
Result on the web
<a href="http://dx.doi.org/10.1016/j.jns.2014.04.026" target="_blank" >http://dx.doi.org/10.1016/j.jns.2014.04.026</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jns.2014.04.026" target="_blank" >10.1016/j.jns.2014.04.026</a>

Result language
angličtina
Original language name
Thalamic atrophy and cognitive impairment in clinically isolated syndrome and multiple sclerosis
Original language description
Background: Cognitive deficits worsen the quality of life in multiple sclerosis and may be predicted by deep gray matter atrophy, especially thalamic atrophy. This relationship has not been studied in the clinically isolated syndrome (CIS). The aims of this study were to assess cognitive deficits in patients with CIS and relapsing-remitting multiple sclerosis (RRMS) using neuropsychological testing, to search for thalamic atrophy on brain MRI, and to test for their correlations. Methods: Forty-three patients (19 With CIS and 24 with RRMS) underwent brain MRI and neuropsychological testing involving multiple cognitive domains and the severity of depression. Thalamic volumes automatically segmented from MRI data were compared to 19 healthy controls. Correlations were sought between cognitive performance and thalamic volume. Results: Cognitive impairment was detected in the majority of both CIS and MS patients, most affected in executive functions, auditory memory, lexical verbal fluency,
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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