Longitudinal MRI and neuropsychological assessment of patients with clinically isolated syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10281142" target="_blank" >RIV/00216208:11110/14:10281142 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/14:10281142

Result on the web

<a href="http://dx.doi.org/10.1007/s00415-014-7413-9" target="_blank" >http://dx.doi.org/10.1007/s00415-014-7413-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00415-014-7413-9" target="_blank" >10.1007/s00415-014-7413-9</a>

Result language

angličtina

Original language name

Longitudinal MRI and neuropsychological assessment of patients with clinically isolated syndrome

Original language description

Cognitive impairment (CI) may occur in clinically isolated syndrome (CIS) patients. While the relationship between CI and magnetic resonance imaging (MRI) has been investigated extensively in multiple sclerosis (MS), MRI correlates of CI in CIS patientsare unknown. To investigate the evolution of CI and to determine brain MRI structural correlates associated with CI in CIS patients. This prospective 24-month observational study examined 81 CIS patients treated with 30 A mu g of intramuscular interferonbeta 1a once a week. MRI acquisition and neuropsychological (NP) assessment were performed at baseline, 6, 12 and 24 months. Participants were tested with Czech-validated version of Minimal Assessment of Cognitive Function in MS battery and MRI measuresof lesion activity and burden, and global, tissue-specific and regional brain atrophy were performed. Over 24 months, 36 CIS patients developed clinically definite MS (CDMS). CI was observed in 10 (12.3 %) CIS patients at baseline and at

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NT13237" target="_blank" >NT13237: Clinical and paraclinical markers of multiple sclerosis – description and prediction of disease activity</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neurology

ISSN

0340-5354

e-ISSN

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Volume of the periodical

261

Issue of the periodical within the volume

9

Country of publishing house

DE - GERMANY

Number of pages

10

Pages from-to

1735-1744

UT code for WoS article

000341791300010

EID of the result in the Scopus database

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