Nonmyocytic androgen receptor regulates the sexually dimorphic development of the embryonic bulbocavernosus muscle

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10272412" target="_blank" >RIV/00216208:11110/14:10272412 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1210/en.2014-1008" target="_blank" >http://dx.doi.org/10.1210/en.2014-1008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1210/en.2014-1008" target="_blank" >10.1210/en.2014-1008</a>

Result language

angličtina

Original language name

Nonmyocytic androgen receptor regulates the sexually dimorphic development of the embryonic bulbocavernosus muscle

Original language description

The bulbocavernosus (BC) is a sexually dimorphic muscle observed only in males. Androgen receptor knockout mouse studies show the loss of BC formation. This suggests that androgen signaling plays a vital role in its development. Androgen has been known to induce muscle hypertrophy through satellite cell activation and myonuclei accretion during muscle regeneration and growth. To identify the mechanism of sexual dimorphism during BC embryonic development, the timing of morphological differences was firstestablished. The BC was morphologically different between male and female mice at embryonic day (E) 16.5. Differences in the myogenic process were detected at E15.5. The male BC possesses a higher number of proliferating undifferentiated myoblasts. To identify the role of androgen signaling, muscle-specific androgen receptor (AR) mutation was introduced, which resulted in no observable phenotypes. Hence, the expression of AR in the BC was examined and found that the AR did not colocaliz

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Endocrinology

ISSN

0013-7227

e-ISSN

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Volume of the periodical

155

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

2467-2479

UT code for WoS article

000342343400015

EID of the result in the Scopus database

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