Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10282788" target="_blank" >RIV/00216208:11110/14:10282788 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/14:00432084 RIV/00064190:_____/14:#0000802 RIV/68407700:21340/14:00223755 RIV/00216208:11120/14:43908600

Result on the web

<a href="http://ar.iiarjournals.org/content/34/7/3511" target="_blank" >http://ar.iiarjournals.org/content/34/7/3511</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma

Original language description

Aim: We investigated differences of metastatic spread of normal proteinase-activated receptor-2 (Par2(+/+)) melanoma B16 in Par2(-/-) (knock-out) animals compared to C57Bl6 mice. Materials and Methods: Nine knock-out mice B6.Cg-F2rl1tm1Mslb/J (Par2(-/-))and nine C57Bl6/J controls were subcutaneously inoculated with B16 melanoma tissue cells. Twelve days after inoculation, all primary tumors were removed. Survival and metastatic spread was followed for up to 100 days after primary tumor extirpation. Results: Excised primary tumors were on average larger in Par2(-/-) mice (360 mm(3) vs. 221 mm(3) in C57Bl6/J). Distant spontaneous metastases developed in only 3 of 9 of Par2(-/-) mice in comparison to 6 of 9 controls. The average survival time was 84 daysin Par2(-/-) animals compared to 63 days in C57Bl6/J mice. Conclusion: Host Par2 melanoma model contributes to the limitation of local cancer progression in one area, while on the other hand is important for enhancing distant metastatic

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

7

Country of publishing house

GR - GREECE

Number of pages

5

Pages from-to

3511-3515

UT code for WoS article

000338780300036

EID of the result in the Scopus database

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