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PAR2 knock-out C57Bl6 mice as a model for evaluating metastases of cancer cells: pilot in vivo study of the metastatic potential of B16 melanoma in knock-out (PAR2-/-) animals

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A13229" target="_blank" >RIV/00216208:11110/12:13229 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064190:_____/12:#0000311 RIV/68407700:21340/12:00199955 RIV/00216208:11120/12:43898176

  • Result on the web

    <a href="http://fb.cuni.cz/file/5640/FB2012A0013.pdf" target="_blank" >http://fb.cuni.cz/file/5640/FB2012A0013.pdf</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    PAR2 knock-out C57Bl6 mice as a model for evaluating metastases of cancer cells: pilot in vivo study of the metastatic potential of B16 melanoma in knock-out (PAR2-/-) animals

  • Original language description

    Metastatic spread was observed in both groups and reached 80 % in PAR2-/- and 50 % in control animals. While in control mice only lung metastases were observed, local tumour recurrence, renal and lung metastases were observed in PAR2-/- mice. The absenceof functional PAR-2 could be an important factor influencing the growth and spread of melanoma in vivo, probably associated with tumour cell migration, invasiveness and metastasis formation.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Folia Biologica

  • ISSN

    0015-5500

  • e-ISSN

  • Volume of the periodical

    58

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    6

  • Pages from-to

    81-86

  • UT code for WoS article

    000303140600006

  • EID of the result in the Scopus database