Deletion of protease-activated receptor 2 prolongs survival of scrapie-inoculated mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43907120" target="_blank" >RIV/00216208:11120/12:43907120 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/12:00389996 RIV/00064190:_____/12:#0000300 RIV/00216208:11110/12:11719
Result on the web
<a href="http://dx.doi.org/10.1099/vir.0.043877-0" target="_blank" >http://dx.doi.org/10.1099/vir.0.043877-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1099/vir.0.043877-0" target="_blank" >10.1099/vir.0.043877-0</a>
Alternative languages
Result language
angličtina
Original language name
Deletion of protease-activated receptor 2 prolongs survival of scrapie-inoculated mice
Original language description
Proteinase-activated receptor 2 (PAR2) has recently been identified to be a possible modulator of neurodegeneration. To investigate whether PAR2 plays a role in prion infection, we inoculated PAR2-deficient (PAR2(-/-)) and wild-type (WT) mice intracerebrally with the Rocky Mountain Laboratory strain of scrapie. PAR2(-/-) mice demonstrated a delayed onset of clinical symptoms, including weight loss, and demonstrated moderate but highly significant prolongation of survival over WT controls. Concomitantly,no apparent differences in brain pathology, infectivity or features of brain prion protein between deceased WT and PAR2(-/-) mice were found. Our study suggests that PAR2 deletion modulates dynamics of the disease without gross perturbation of its pathogenesis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of General Virology
ISSN
0022-1317
e-ISSN
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Volume of the periodical
93
Issue of the periodical within the volume
Part 9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
2057-2061
UT code for WoS article
000309035100025
EID of the result in the Scopus database
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