Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10283651" target="_blank" >RIV/00216208:11110/14:10283651 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-3-642-45198-0_9" target="_blank" >http://dx.doi.org/10.1007/978-3-642-45198-0_9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-642-45198-0_9" target="_blank" >10.1007/978-3-642-45198-0_9</a>
Alternative languages
Result language
angličtina
Original language name
Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis
Original language description
Myeloid cells constitute the innate arm of the vertebrate immune system and arise from haematopoietic stem cells being committed to their cell fate through a series of lineage restrictions regulated by a gene regulatory network. This gene network consists of transcription factors as well as components of the epigenetic machinery that, in cooperation with one another, will programme progenitors to adopt and differentiate along a certain lineage programme. By virtue of their obligatory function, dysregulation in the activity of these regulatory factors can contribute to the pathogenesis of myeloid leukaemias. To understand the molecular aetiology of myeloid dysplasias it is imperative to first study and model the network that regulates normal development. Equipped with this crucial understanding we can then begin to decipher what, how and why things have gone wrong in the pathology of myeloid leukaemias.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Epigenetics and Human Health
ISBN
978-3-642-45197-3
Number of pages of the result
13
Pages from-to
233-245
Number of pages of the book
416
Publisher name
Springer-Verlag Berlin Heidelberg
Place of publication
Heidelberg
UT code for WoS chapter
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