Control of myeloid lineage fidelity and response to stimuli by ISWI-enforced nucleosome phasing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10504949" target="_blank" >RIV/00216208:11110/25:10504949 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=36czEYKxN~" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=36czEYKxN~</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.immuni.2025.09.002" target="_blank" >10.1016/j.immuni.2025.09.002</a>
Alternative languages
Result language
angličtina
Original language name
Control of myeloid lineage fidelity and response to stimuli by ISWI-enforced nucleosome phasing
Original language description
The interplay between chromatin remodelers and pioneer transcription factors (TFs) regulates cis-regulatory element accessibility to maintain cell identity and transcriptional fidelity. We investigated the impact of imitatiation and activation, focusing on SMARCA5, the sole ISWI ATPase in myeloid cells. Conditional Smarca5 a pioneer TF essential for myeloid identity, without altering PU.1 occupancy. However, SMARCA5 loss increased accessibility at motifs bound by C/EBP beta, a weak pioneer TF, enabling binding to regulatory regions active in non-hematopoietic lineages and causing lineage-inappropriate transcription. These changes also increased accessibility at sites bound by stimulus-induced TFs, leading to macrophage hyperactivation and mis-expression of stimulus-inappropriate genes. Thus, SMARCA5-dependent nucleosome phasing respecification and activation, with likely similar roles in other immune cell types.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Immunity
ISSN
1074-7613
e-ISSN
1097-4180
Volume of the periodical
58
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
26
Pages from-to
2402-"2418.e8"
UT code for WoS article
001600265600003
EID of the result in the Scopus database
2-s2.0-105018211900