Change in ploidy status from hyperdiploid to near-tetraploid in multiple myeloma associated with bortezomib/lenalidomide resistance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284173" target="_blank" >RIV/00216208:11110/14:10284173 - isvavai.cz</a>

Alternative codes found

RIV/00023736:_____/14:00010820 RIV/00064165:_____/14:10284173

Result on the web

<a href="http://dx.doi.org/10.1016/j.cancergen.2014.06.027" target="_blank" >http://dx.doi.org/10.1016/j.cancergen.2014.06.027</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cancergen.2014.06.027" target="_blank" >10.1016/j.cancergen.2014.06.027</a>

Result language

angličtina

Original language name

Change in ploidy status from hyperdiploid to near-tetraploid in multiple myeloma associated with bortezomib/lenalidomide resistance

Original language description

Ploidy is an MM can be divided into two groups according to the modal number of chromosomes: nonhyperdiploid (NH-MM) and hyperdiploid (H-MM), which has a more favorable outcome. The two ploidy groups represent two different oncogenetic pathways determined at the premalignant stage. The ploidy subtype also persists during the course of the disease, even during progression after the therapy, with only very rare cases of ploidy conversion. The clinical significance of ploidy conversion and its relation todrug resistance have been previously discussed. Here, we describe a female MM patient with a rare change in her ploidy status from H-MM to NH-MM, detected by cytogenetic and molecular cytogenetic examinations of consecutive bone marrow aspirates. We hypothesize that ploidy conversion (from H-MM to NH-MM) is associated with disease progression and acquired resistance to bortezomibilenalidomide therapy.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer genetics

ISSN

2210-7762

e-ISSN

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Volume of the periodical

207

Issue of the periodical within the volume

7-8

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

326-331

UT code for WoS article

000345254700005

EID of the result in the Scopus database

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