GSK3 beta, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284184" target="_blank" >RIV/00216208:11110/14:10284184 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/14:10284184

Result on the web

<a href="http://dx.doi.org/10.1016/j.pnpbp.2013.12.001" target="_blank" >http://dx.doi.org/10.1016/j.pnpbp.2013.12.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pnpbp.2013.12.001" target="_blank" >10.1016/j.pnpbp.2013.12.001</a>

Result language

angličtina

Original language name

GSK3 beta, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression

Original language description

Background: Glycogen synthase kinase-3 beta (GSK3 beta), cAMP-response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) play critical roles in neuronal survival, synaptic plasticity and memory and participate in the pathophysiology of both depressive disorder and Alzheimer's disease (AD). Methods: This study was designed to determine the association of GSK3 beta activity, CREB activity and BDNF concentration in peripheral blood of patients with AD with or without depressive symptoms and in depressive patients without AD. GSK3 beta activity in platelets, CREB activity in lymphocytes and BDNF concentration in plasma, platelet-rich plasma or platelets were measured in 85 AD patients (36 of whom displayed co-morbid depressive symptoms), 65 non-AD patients with depressive disorder and 96 healthy controls. AD patients were clinically assessed for stage of dementia, cognitive impairment and severity of depressive symptoms. Depressive patients were clinically assesse

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Progress in Neuro-Psychopharmacology and Biological Psychiatry

ISSN

0278-5846

e-ISSN

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Volume of the periodical

50

Issue of the periodical within the volume

April

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

83-93

UT code for WoS article

000330574000010

EID of the result in the Scopus database

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