Systemic AL amyloidosis with unusual cutaneous presentation unmasked by carotenoderma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284281" target="_blank" >RIV/00216208:11110/14:10284281 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/14:00440682 RIV/00216224:14110/14:00074885 RIV/00216305:26310/14:PU107282 RIV/00064165:_____/14:10284281
Result on the web
<a href="http://dx.doi.org/10.3109/13506129.2013.851076" target="_blank" >http://dx.doi.org/10.3109/13506129.2013.851076</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/13506129.2013.851076" target="_blank" >10.3109/13506129.2013.851076</a>
Alternative languages
Result language
angličtina
Original language name
Systemic AL amyloidosis with unusual cutaneous presentation unmasked by carotenoderma
Original language description
We present a case study of an elderly woman with systemic lambda-type AL amyloidosis that featured unusually extensive cutaneous involvement. The case initially presented with a sudden hyper beta-carotenemia with carotenoderma that instigated the clinical examination including skin biopsy. A diagnosis of systemic amyloidosis was made. Immunohistochemistry and Western-blot analysis indicated the presence of lambda light chain proteins in skin amyloid deposits. However, notable co-deposition of wild-typeapoA-I and transthyretin was observed which caused initial diagnostic confusion. Proteomic analysis of microdissected skin amyloid deposits by mass spectrometry confirmed lambda light chain proteins in amyloid deposits and co-deposition of apolipoproteinA-IV and serum amyloid P-component. The patient died from renal failure caused by amyloid nephropathy combined with analgesic nephropathy. The autopsy disclosed vascular, cardiac, renal and pulmonary amyloid deposition. While all amyloid
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
ISSN
1350-6129
e-ISSN
—
Volume of the periodical
21
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
57-61
UT code for WoS article
000335764200009
EID of the result in the Scopus database
—