Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284369" target="_blank" >RIV/00216208:11110/14:10284369 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/14:00430218 RIV/68378041:_____/14:00430218

Result on the web

<a href="http://dx.doi.org/10.1186/1471-2350-15-17" target="_blank" >http://dx.doi.org/10.1186/1471-2350-15-17</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1471-2350-15-17" target="_blank" >10.1186/1471-2350-15-17</a>

Result language

angličtina

Original language name

Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients

Original language description

Background: Mismatch repair (MMR) genes are known to be frequently altered in colorectal cancer (CRC). Both genetics and epigenetics modifications seems to be relevant in this phenomenon, however it is still not clear how these two aspects are interconnected. The present study aimed at characterizing of epigenetic and gene expression profiles of MMR genes in sporadic CRC patients from the Czech Republic, a country with one of the highest incidences of this cancer all over Europe. Methods: Expression levels and CpG promoter methylation status of all MMR genes were evaluated in DNA from tumor and adjacent mucosal samples of 53 incident CRC patients. Results: We have found significantly increased transcription levels in EXO1 gene in tumor tissues (P = 0.05) and significant over-expression of MSH3 gene in colon tumors when compared to adjacent mucosal tissues (P = 0.02). Interestingly, almost all MMR genes were differently expressed when localization of tumors was compared. In particular,

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Medical Genetics

ISSN

1471-2350

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

January

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

1-9

UT code for WoS article

000334531400001

EID of the result in the Scopus database

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