Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284431" target="_blank" >RIV/00216208:11110/14:10284431 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/14:00432492 RIV/68378041:_____/14:00432492
Result on the web
<a href="http://dx.doi.org/10.1016/j.dnarep.2014.01.016" target="_blank" >http://dx.doi.org/10.1016/j.dnarep.2014.01.016</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dnarep.2014.01.016" target="_blank" >10.1016/j.dnarep.2014.01.016</a>

Result language
angličtina
Original language name
Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity
Original language description
The interplay between dietary habits and individual genetic make-up is assumed to influence risk of cancer, via modulation of DNA integrity. Our aim was to characterize internal and external factors that underlie inter-individual variability in DNA damage and repair and to identify dietary habits beneficial for maintaining DNA integrity. Habitual diet was estimated in 340 healthy individuals using a food frequency questionnaire and biomarkers of antioxidant status were quantified in fasting blood samples. Markers of DNA integrity were represented by DNA strand breaks, oxidized purines, oxidized pyrimidines and a sum of all three as total DNA damage. DNA repair was characterized by genetic variants and functional activities of base and nucleotide excision repair pathways. Sex, fruit-based food consumption and XPG genotype were factors significantly associated with the level of DNA damage. DNA damage was higher in women (p = 0.035). Fruit consumption was negatively associated with the nu
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—

Project
<a href="/en/project/GAP304%2F12%2F1585" target="_blank" >GAP304/12/1585: Molecular DNA repair characteristics in CRC tumor tissue</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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