DNA Damage and Nucleotide Excision Repair Capacity in Healthy Individuals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10112359" target="_blank" >RIV/00216208:11310/11:10112359 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/11:00367811 RIV/75010330:_____/11:00009334 RIV/00216208:11130/11:7098 RIV/00064190:_____/11:#0000173
Result on the web
<a href="http://dx.doi.org/10.1002/em.20650" target="_blank" >http://dx.doi.org/10.1002/em.20650</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/em.20650" target="_blank" >10.1002/em.20650</a>
Alternative languages
Result language
angličtina
Original language name
DNA Damage and Nucleotide Excision Repair Capacity in Healthy Individuals
Original language description
Interindividual differences in DNA repair capacity (DRC) represent an important source of variability in genome integrity and thus influence health risk. In the last decade, DRC measurement has attracted attention as a potential biomarker in cancer prediction. Aim of the present exploratory study was to characterize the variability in DNA damage and DRC on 100 healthy individuals and to identify biological, lifestyle, or genetic factors modulating these parameters. The ultimate goal was to obtain reference data from cancer-free population, which may constitute background for further investigations on cancer patients. The endogenous DNA damage was measured as a level of DNA single-strand breaks and DRC, specific for nucleotide excision repair (NER), wasevaluated using modified comet assay, following the challenge of peripheral blood mononuclear cells with benzo[a]pyrene diolepoxide. Additionally, genetic polymorphisms in NER genes (XPA, XPC, XPD, and XPG) were assessed. We have observe
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental and Molecular Mutagenesis
ISSN
0893-6692
e-ISSN
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Volume of the periodical
52
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
511-517
UT code for WoS article
000294182300001
EID of the result in the Scopus database
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