Differences in nucleotide excision repair capacity between newly diagnosed colorectal cancer patients and healthy controls

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11932" target="_blank" >RIV/00216208:11110/12:11932 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/12:00373763 RIV/00064190:_____/12:#0000308 RIV/00216208:11130/12:8042 RIV/00669806:_____/12:10119064 and 3 more
Result on the web
<a href="http://dx.doi.org/10.1093/mutage/ger088" target="_blank" >http://dx.doi.org/10.1093/mutage/ger088</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Differences in nucleotide excision repair capacity between newly diagnosed colorectal cancer patients and healthy controls
Original language description
Alteration of DNA integrity is a potential cause of cancer and it is assumed that reduced DNA repair capacity and accumulation of DNA damage may represent intermediate markers in carcinogenesis. In this case-control study, DNA damage and nucleotide excision repair capacity (NER-DRC) were assessed in association with sporadic colorectal cancer (CRC). Both parameters were quantified by comet assay in blood cells of 70 untreated incident patients and 70 age-matched healthy controls. mRNA expression and polymorphisms in relevant NER genes were concurrently analyzed. The aim of this study was to characterize incident CRC patients for NER-DRC and to clarify possible relations between investigated variables. Comet assay and mRNA expression analysis showed that CRC patients differ in repair capacity as compared to controls. Patients had a lower NER-DRC and simultaneously they exhibited higher endogenous DNA damage (for both P < 0.001). Accumulation of DNA damage and decreasing NER-DRC behaved
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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