Post-treatment recovery of suboptimal DNA repair capacity and gene expression levels in colorectal cancer patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F14%3A00432485" target="_blank" >RIV/68378041:_____/14:00432485 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/14:00432485 RIV/00064190:_____/15:#0001046 RIV/00216208:11310/15:10285710 RIV/00216208:11110/15:10285710 and 2 more
Result on the web
<a href="http://dx.doi.org/10.1002/mc.22141" target="_blank" >http://dx.doi.org/10.1002/mc.22141</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mc.22141" target="_blank" >10.1002/mc.22141</a>
Alternative languages
Result language
angličtina
Original language name
Post-treatment recovery of suboptimal DNA repair capacity and gene expression levels in colorectal cancer patients
Original language description
DNA repair in blood cells was observed to be suboptimal in cancer patiens at diagnosis, including colorectal cancer (CRC). We studied the dynamics of DNA repair from diagnosis to 1 yr follow-up, and with respect to CRC treatment. CRC patients were blood-sampled three times in 6-mo intervals, starting at the diagnosis, and compared to healthy controls. DNA repair was characterized by mRNA levels of 40 repair genes, by capacity of nucleotide exciton repair (NER), and by levels of DNA strand breaks (SBs). NER and base excision repair genes were significantly under-expressed (P<0.02) in patients at diagnosis compared to controls, in accordance with reduced NER function (P<0.031) and increased SBs (P<0.013). Six months later, there was an increase of NER capacity, but not of gene expression levels, in treated patients only. A year from diagnosis, gene expression profiles and NER capacity were significantly modified in all patients and were no longer different from those measured in controls. All patients were free of relapse at the last sampling, so we were unable to clarify the impact of DNA repair parameters on treatment response. However, we identified a panel of blood DNA repair-related markers discerning acute stage of the disease from the remission period.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Carcinogenesis
ISSN
0899-1987
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
769-778
UT code for WoS article
000359710600011
EID of the result in the Scopus database
2-s2.0-84894676129