DNA damage and nucleotide excision repair capacity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002564" target="_blank" >RIV/60162694:G44__/11:00002564 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/em.20650" target="_blank" >http://dx.doi.org/10.1002/em.20650</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
DNA damage and nucleotide excision repair capacity
Original language description
Inter-individual differences in DNA repair capacity (DRC) pose an important source of variability in maintenance of genome integrity and thus influencing a predisposition to cancer. Aim of this study was to develop a simple, but comprehensive, nucleotideexcision repair (NER)-specific challenge assay to measure DRC of DNA damage induced by Benzo[a]pyrene diolepoxide (BPDE). DRC has been evaluated in peripheral blood lymphocytes of 70 healthy individuals. In the same subjects, endogenous DNA damage in the form of single-strand breaks was measured. For the comparison of NER-specific DRC as a result of specific DNA damage induced by chemical and radiation stress, a parallel application of BPDE and ultraviolet (UV) light was conducted in a subgroup of 24 individuals.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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