6S RNA modulates growth and antibiotic production in Streptomyces coelicolor
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10285295" target="_blank" >RIV/00216208:11110/14:10285295 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/14:00433200 RIV/60461373:22330/14:43897653
Result on the web
<a href="http://dx.doi.org/10.1007/s00253-014-5806-4" target="_blank" >http://dx.doi.org/10.1007/s00253-014-5806-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00253-014-5806-4" target="_blank" >10.1007/s00253-014-5806-4</a>
Alternative languages
Result language
angličtina
Original language name
6S RNA modulates growth and antibiotic production in Streptomyces coelicolor
Original language description
The aim of this study was to contribute to clarifying the role of 6S RNA in the development and control of antibiotic biosynthesis in Streptomyces coelicolor. Due to the low energetic cost of gene silencing via 6S RNA, it is an easy and rapid means of down-regulating the expression of specific genes in response to signals from changes in the environment. The expression of 6S RNA in S. coelicolor is not constitutive, and its accumulation is adapted to changes in nutritional conditions. The 6S RNA of S. coelicolor is capable of interacting with RNA polymerase beta beta' subunits and is a template for the transcription of short pRNAs. Deletion of the ssrS gene from S. coelicolor affects the growth rate and causes changes in the expression of several pathway-specific genes involved in actinorhodin biosynthesis. The complementation of the Delta ssrS strain with ssrS gene restored the wild-type levels of growth and actinorhodin production. We conclude that 6S RNA contributes to the optimizat
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Applied Microbiology and Biotechnology
ISSN
0175-7598
e-ISSN
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Volume of the periodical
98
Issue of the periodical within the volume
16
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
7185-7197
UT code for WoS article
000340087600026
EID of the result in the Scopus database
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