6S-Like scr3559 RNA Affects Development and Antibiotic Production in Streptomyces coelicolor

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F21%3A43896487" target="_blank" >RIV/44555601:13440/21:43896487 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10434358

Result on the web

<a href="https://www.mdpi.com/2076-2607/9/10/2004" target="_blank" >https://www.mdpi.com/2076-2607/9/10/2004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/microorganisms9102004" target="_blank" >10.3390/microorganisms9102004</a>

Result language

angličtina

Original language name

6S-Like scr3559 RNA Affects Development and Antibiotic Production in Streptomyces coelicolor

Original language description

Regulatory RNAs control a number of physiological processes in bacterial cells. Here we report on a 6S-like RNA transcript (scr3559) that affects both development and antibiotic production in Streptomyces coelicolor. Its expression is enhanced during the transition to stationary phase. Strains that over-expressed the scr3559 gene region exhibited a shortened exponential growth phase in comparison with a control strain; accelerated aerial mycelium formation and spore maturation; alongside an elevated production of actinorhodin and undecylprodigiosin. These observations were supported by LC-MS analyses of other produced metabolites, including: germicidins, desferrioxamines, and coelimycin. A subsequent microarray differential analysis revealed increased expression of genes associated with the described morphological and physiological changes. Structural and functional similarities between the scr3559 transcript and 6S RNA, and its possible employment in regulating secondary metabolite production are discussed.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Microorganisms

ISSN

2076-2607

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

10

Country of publishing house

CH - SWITZERLAND

Number of pages

18

Pages from-to

"nestrankovano"

UT code for WoS article

000713142400001

EID of the result in the Scopus database

2-s2.0-85115421282