Cellular and humoral immunodeficiency in breast cancer patients resistant to hormone therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10286158" target="_blank" >RIV/00216208:11110/14:10286158 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/14:10286158
Result on the web
<a href="http://dx.doi.org/10.4149/neo_2014_013" target="_blank" >http://dx.doi.org/10.4149/neo_2014_013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2014_013" target="_blank" >10.4149/neo_2014_013</a>
Alternative languages
Result language
angličtina
Original language name
Cellular and humoral immunodeficiency in breast cancer patients resistant to hormone therapy
Original language description
In view of the fact that insufficiency in immune response often correlates with poor prognosis, research in recent years has focused on the task of describing the precise status and function of the immune system and its possible effect on cancer patients. Although more than two thirds of treated patients respond to endocrine therapy, most patients with metastatic breast cancer develop a resistance to it. Estrogen modulates angiogenesis, partially through its effects on vascular endothelial growth factor(VEGF). It also appears that transforming growth factor-beta (TGF beta) could be another factor contributing to this resistance. TGF beta is a highly immunosuppressive factor that inhibits natural and specific immunity against tumors and stimulates theproduction of VEGF.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
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Volume of the periodical
61
Issue of the periodical within the volume
1
Country of publishing house
SK - SLOVAKIA
Number of pages
9
Pages from-to
90-98
UT code for WoS article
000329769500013
EID of the result in the Scopus database
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