What are the implications of human papillomavirus status in oropharyngeal tumors for clinical practice?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10288150" target="_blank" >RIV/00216208:11110/14:10288150 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/14:10288150 RIV/00023736:_____/14:00011026
Result on the web
<a href="http://dx.doi.org/10.1097/MOO.0000000000000030" target="_blank" >http://dx.doi.org/10.1097/MOO.0000000000000030</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MOO.0000000000000030" target="_blank" >10.1097/MOO.0000000000000030</a>
Alternative languages
Result language
angličtina
Original language name
What are the implications of human papillomavirus status in oropharyngeal tumors for clinical practice?
Original language description
Purpose of reviewHuman papillomavirus (HPV) status itself is an important and very probably the strongest prognostic factor in head and neck cancer. Because of the prognostic advantage of patients with HPV-positive cancers, the issue of the quality of life of survivors has become increasingly important. The possibility of treatment de-escalation in patients with virally induced tumors is being considered. Many challenges have to be addressed in order to integrate HPV status in the routine decision-making in patients with oropharyngeal cancer. The present review discusses the standardization of detection methods suitable for clinical use and the differences in predictive parameters between patients with HPV-positive and HPV-negative tumors.Recent findingsThe gold standard for the identification of patients with oropharyngeal tumors etiologically linked to HPV infection is undoubtedly the detection of HPV 16 E6/E7 mRNA. The detection of a surrogate marker of active viral infection, p16in
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT12483" target="_blank" >NT12483: Relation of viral etiology of oropharyngeal tumors to the response rate of individual treatment modalities</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Opinion in Otolaryngology and Head and Neck Surgery
ISSN
1068-9508
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
90-94
UT code for WoS article
000333287400002
EID of the result in the Scopus database
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